Understanding the factors that affect bubble dissolution under pressure is crucial for the pneumatic transport of dispersions. This study probes the kinetics of air dissolution, the air solubility at a given pressure, and the gas diffusion due to bubble dissolution to elucidate the molecular mechanisms of gas transport in liquid dispersions with varied structures and viscosities. We achieve our aims by using water-glycerol mixtures, silicone oils with different viscosities, surfactant solutions containing worm-like micelles and having different macroscopic viscosities, particle suspensions, and surfactant solutions capable of forming a condensed adsorption layer on the bubble surfaces at ambient conditions. The results show that the dissolution rate does not depend on the macroscopic viscosity for silicone oils and solutions containing worm-like micelles, indicating that gas diffusion occurs faster than the movement of big polymeric molecules and worm-like micelles. We could predict the experimentally determined diffusion coefficients by accounting for free volume in these media and using the equation for Knudsen diffusion. We show that one way to decrease the rate of bubble dissolution under pressure is to add surfactants, which can decrease the permeability of the adsorption layer formed on the bubble surface by forming a condensed adsorption layer.

Hydroxypropyl cellulose (HPC) is a non-digestible water-soluble polysaccharide used in various food, cosmetic, and pharmaceutical applications. In the current study, the aqueous solutions of six HPC grades, with molecular mass ranging from 40 to 870 kDa, were characterized with respect to their precipitation temperatures, interfacial tensions (IFTs), rheological properties and emulsifying and stabilization ability in palm (PO) and sunflower (SFO) oil emulsions. The main conclusions from the obtained results are as follows: (1) Emulsion drop size follows a master curve as a function of HPC concentration for all studied polymers, indicating that polymer molecular mass and solution viscosity have a secondary effect, while the primary effect is the fraction of surface-active molecules, estimated to be around 1–2% for all polymers. (2) Stable emulsions were obtained only with HPC polymers with Mw ≥ 400 kDa at concentrations approximately 3.5 times higher than the critical overlap concentration, c*. At PO concentrations beyond 40 wt. % or when the temperature was 25 °C, these emulsions appeared as highly viscous liquids or non-flowing gels. (3) HPC polymers with Mw < 90 kDa were unable to form stable emulsions, as the surface-active molecules cannot provide steric stabilization even at c ≳ 4–5 c*, resulting in drop creaming and coalescence during storage.

The rheological properties of disperse systems play a crucial role in the production of foods, cosmetics, and pharmaceuticals with desired characteristics. Emulsion viscosity can be increased through various methods, incl. increasing the oil volume fraction, incorporating rheological modifiers, or inducing partial coalescence between the droplets. It is well known that suspensions containing inorganic non-spherical particles often exhibit significantly higher viscosities when compared to those with spherical particles. The spontaneous drop self-shaping phenomenon in emulsions, first reported in detail by Denkov et al. (Nature, 2015, 528, 392–395), enables the formation of fluid and frozen lipid particles with regular non-spherical shapes, including platelets, rods and fibers. In this study, we utilize this approach to prepare emulsions containing non-spherical frozen particles of various shapes and investigate their rheological properties. The effects of oil volume fraction, surfactant type, initial drop size and polydispersity are investigated. The results reveal that non-flowing, gel-like samples can be prepared at ca. 11 vol% oil fraction when the emulsion contains polydisperse droplets which acquire non-spherical shapes upon cooling. For comparison, more than ca. 65 vol% oil is needed to obtain similar rheological characteristics in samples containing spherical particles. Additionally, we demonstrate that the optimal drop size for gel preparation is d32 ≈ 4–13 μm. The obtained results are explained mechanistically, and guiding principles are provided for preparing emulsions with increased viscosities using this new approach.

Background and aims
Nanotechnology provides the opportunity for construction of modern transport devices such as nanoparticles for a variety of applications in the field of medicine. A novel experimental protocol for the formation of saponin-cholesterol-phospholipid nanoparticles of vesicular structure has been developed and applied to prepare stable nanoparticles using escin or glycyrrhizin as saponins.
Methods
The methods for nanoparticle construction include a sonication at 90 °C of the initial mixture of components, followed by an additional sonication on the next day for incorporation of an additional amount of cholesterol, thus forming stable unilamellar vesicles. Tests and assays for cell viability, erythrocyte hemolysis, flow cytometry, and fluorescent microscopy analyses have been performed.
Results
By selecting appropriate component ratios, stable and safe particles were formulated with respect to the tested bio-cells. The prepared nanoparticles have mean diameter between 70 and 130 nm, depending on their composition. The versatility of these nanoparticles allows for the encapsulation of various molecules, either within the vesicle interior for water-soluble components or within the vesicle walls for hydrophobic components. The saponin particles formed after cholesterol post-addition (E3-M2) are stable and 100 % of the cells remain viable even after 10-times dilution of the initial particle suspension. These particles are successful included into isolated mouse macrophages.
Conclusions
Among the variety of generated nanoparticles, the E3-M2 particles demonstrated properties of safe and efficient devices for future vaccine design and antigen targeting to immune system.

Hypothesis
Solubilization is a fundamental process that underpins various technologies in the pharmaceutical and chemical industry. However, knowledge of the location, orientation and interactions of solubilized molecules in the micelles is still limited. We expect all-atom molecular dynamics simulations to improve the molecular-level understanding of solubilization and to enable its in silico prediction.
Methods
The solubilization of six drugs in intestinal mixed micelles composed of taurocholate and dioleoyl phosphatidylcholine was simulated by molecular dynamics in explicit water and measured experimentally by liquid chromatography. The location and orientation of the solubilized drugs were visualized by cumulative radial distribution functions and interactions were characterized by radial distribution function ratios and hydrogen bonding.
Findings
A new simulation-derived parameter was defined, which accounts for drug-micelle and drug-water interactions and correlates (R2 = 0.83) with the experimentally measured solubilization. Lipophilicity was found to govern the location of all drugs in the micelle (hydrophobic core, palisade layer or on the surface), while hydrogen bonding was crucial for orientation and solubilization of two of the molecules. The study demonstrates that explicit, hydrogen bond-forming water molecules are vital for accurate prediction of solubilization and provides a comprehensive framework for quantitative studies of drug location and orientation within the micelles.